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NFL Wild Card Weekend: Game Picks, Predictions, Schedule & Betting Odds

Suraay

1/10/20261 min read

The wild-card round of the 2025 NFL playoffs features six compelling matchups, and we have everything you need to know heading into an action-packed weekend.

The postseason kicked off Saturday, highlighted by Panthers quarterback Bryce Young making his playoff debut against the Rams. Saturday night delivers another chapter in the historic Packers–Bears rivalry. Sunday’s slate includes a marquee quarterback showdown between the Bills’ Josh Allen and the Jaguars’ Trevor Lawrence, a clash between the 49ers and the Eagles, and a cross-country matchup with the Chargers visiting Patriots rookie quarterback Drake Maye. The weekend concludes Monday night with a gritty Texans defense taking on Steelers quarterback Aaron Rodgers.

Our NFL Nation reporters provide behind-the-scenes insight from each team, including the most notable moments they heard in the locker rooms this week. Analytics writer Seth Walder breaks down one key statistic for every matchup, while analyst Ben Solak delivers bold predictions. Matt Bowen highlights one critical X-factor to watch in each game, and betting analyst Pamela Maldonado offers one intriguing wager per contest. Staff writer Kevin Seifert rounds things out with insight into the officiating crews.

In addition, ESPN’s Football Power Index (FPI) supplies game projections, and analysts Eric Moody, Maldonado, Solak, and Walder give their final score predictions for every matchup.

Everything you need to prepare for a loaded weekend of NFL playoff football is right here. Let’s dive into the full wild-card slate.