The San Francisco 49ers head to Philadelphia to face the Eagles on Sunday in a compelling wild-card matchup that also features an intriguing chess match on the sidelines between 49ers head coach Kyle Shanahan and Eagles defensive coordinator Vic Fangio. While Philadelphia continues to search for consistent offensive rhythm, the unit remains dangerous thanks to its collection of explosive playmakers.

Matt Bowen provides a detailed breakdown of the on-field matchups, while Liz Loza, Pamela Maldonado, Eric Moody, Ben Solak and Seth Walder weigh in with their top bets, betting insights and DFS recommendations to help you navigate the action.

Note: Odds courtesy of DraftKings Sportsbook and subject to change.

Game Information

FOX | 4:30 PM ET

San Francisco (12–5, 10–7 ATS)
Philadelphia (11–6, 10–7 ATS)

• Spread: PHI -6

• Total: 44.5

• Moneyline: PHI -265 | SF +215

• Opening line: PHI -3, O/U 46.5

• FPI projection: Eagles by 2.3 points (56.3% win probability)

When the 49ers have the ball

Bowen: Brock Purdy will be working through clearly defined reads against Philadelphia’s split-safety looks. Expect Shanahan to lean heavily on play-action concepts designed to stretch the safeties and open voids in the middle of the field. Christian McCaffrey should see significant volume as both a runner and receiver, and this matchup favors San Francisco’s ground game.

Edge: Eagles

Best bet: McCaffrey OVER 57.5 rushing yards (-111). He has eclipsed 70 rushing yards in five of his past seven games and logged 20-plus carries in five of his last six. Meanwhile, the Eagles have surrendered an average of 141.2 rushing yards per game over their last six contests.

When the Eagles have the ball

Bowen: Philadelphia will aim to establish its offensive identity through the run, with Saquon Barkley as the focal point. Improved movement up front is critical, but the Eagles will also look to take shots downfield to A.J. Brown and DeVonta Smith. Expect isolation routes from both the slot and the boundary, while Jalen Hurts may be asked to extend plays outside the pocket.

Edge: 49ers

Best bet: Brown OVER 5.5 receptions (-105). Brown has recorded at least six catches in three of his past five games and should see steady volume on slants and underneath routes against San Francisco’s zone coverages, with at least one deep target per half likely.

Staff picks & key props

• 49ers +6 (-115)
  Solak: Philadelphia has covered six points only three times since its bye and tends to play conservatively, leaning on defense to protect leads. San Francisco has enough offensive explosiveness to stay within the number, even if trailing late.

• Brock Purdy UNDER 1.5 passing TDs (-170)
  Maldonado: Fangio’s defenses excel in the red zone, forcing long drives and field goals. Purdy may move the ball effectively, but finishing through the air will be challenging.

• Saquon Barkley OVER 2.5 receptions (+102)
  Loza: While Barkley’s receiving usage has dipped, this matchup sets up well against a 49ers defense vulnerable at the second level.

• Christian McCaffrey OVER 45.5 receiving yards (-110)
  Moody: Despite recent dips in production, McCaffrey averages 7.6 targets per game and draws a favorable matchup against an Eagles defense that has allowed significant receiving production to running backs.

• Jordan Davis UNDER 3.5 tackles + assists (-153)
  Walder: This is a high line for a defensive lineman, and San Francisco’s tendency to use McCaffrey in space rather than running directly at Davis favors the under.

DraftKings Captain Showdown – DFS Notes

• Loza’s Captain: A.J. Brown

• Maldonado’s Captain: Jalen Hurts

• Solak’s Captain: Christian McCaffrey

• Walder’s Captain: Saquon Barkley

Each analyst highlights game script, matchup advantages and salary dynamics to build competitive lineups for wild-card weekend.